Year 1908 – «The first immigrants from Japan arrived in Uruguay and settled in the country, mainly in Montevideo».
Year 1921 – «Both countries established diplomatic relations in 1921, which were suspended during the Second World War and reestablished in 1952».
Year 1989 – «Official visit of the President of Uruguay, Julio M. Sanguinetti to Japan, accompanied by a business mission».
Year 2001 – «Official Visit of the President of Uruguay, Jorge Batlle to Japan, accompanied by a business mission».
Year 2001 – «Inauguration of the Japanese Garden of Montevideo».
Year 2003 – «Visit of Her Imperial Highness Sayako, Princess Nori to Uruguay».
Year 2008 – «Visit of Her Imperial Highness, Princess Takamado to Uruguay to celebrate the Centennial of Japanese Immigration to Uruguay».
Years 2009 and 2015 – «Official visit of the President of Uruguay, Tabaré Vázquez, to Japan, accompanied by a business mission».
Year 2015 – «Signing of the Agreement between Uruguay and Japan for the Liberalization, Promotion and Protection of Investments».
Year 2018 – «Official visit of the Japanese Prime Minister, Shinzo Abe, to Uruguay» «During his visit, the Agreement was signed between Prime Minister Abe and the President of Uruguay, Tabaré Vázquez, enabling the entry of Uruguayan boneless meat into the Japanese market»
Year 2019 – «Signing of the Agreement between Japan and Uruguay to eliminate double taxation on income taxes and prevent tax evasion and avoidance».
Year 2021 – «Official Visit of the Minister of Foreign Affairs of Japan, Toshimitsu Motegi to Uruguay».
Year 2021 – «Signing of the Agreement on Mutual Administrative Assistance and Cooperation in Customs Matters, by the Minister of Foreign Affairs of Japan, Toshimitsu Motegi and the Minister of Foreign Affairs of Uruguay Francisco Bustillo, on the occasion of the visit of the Japanese Foreign Minister».